Aiming at obtaining further knowledge on the mode of action of its aquaculture products, Biorigin established in 2014 a partnership for the Project Nowaste, also with participation of UNESP (State University of São Paulo), Jaboticabal campus, Brazil, and Wageningen University, The Netherlands.
The project is funded by the research aid agency of the state of São Paulo (Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP), and the Netherlands Organisation for Scientific Research (NOW), and aims at identifying the receptors responsible for recognizing beta-glucans in carp and pacu macrophages.
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According to Prof Dr Geert Wiegertjes, from Wageningen University, “similarly to cold-water fish such as salmon, carp macrophages are strongly activated by the product MacroGard, as demonstrated by the increase in oxidative burst and gene expression.
“In this project, we intend to demonstrate that this same activation occurs in pacu macrophages. As this activation depends on specific receptors, in a second phase, we will research the receptors responsible for this mechanism in carps and pacus, which may potentially prove that beta-glucans have a similar mode of action both in fish and mammals.”
According to Prof Dr Fabiana Pilarski, from UNESP, “the partnership with Biorigin has now been going for 7 years and has been very fruitful, with the development of 4 research projects to date. Our studies have shown that the product MacroGard acts on the immune system of tropical fish, particularly when reared in intensive systems and during challenge situations, reducing the harmful effects of stress and promoting better performance.
“We also carried out studies with the product ActiveMOS, which was shown to efficiently reduce pathogenic bacteria counts and the number of beneficial bacteria, such as lactobacilli and bifidobacteria, in addition of promoting the development of the structures responsible for nutrient absorption in the gut of fish.”
It is estimated that the aquaculture industry will grow 25 percent in the next few years, and Biorigin has placed 60 percent of its investments in research on animal nutrition, establishing partnerships with universities and research institutes of several countries.
MacroGard
Produced by Biorigin from the cell wall of the yeast Saccharomyces cerevisiae, MacroGard is one of the most studied purified beta-glucans in the world, with proven results such as boosting the immune response and resistance to diseases caused by parasites and viruses, improving vaccine response, and reducing the severity of diseases and mortality.
ActiveMOS
This Biorigin product is rich in MOS (mannan-oligosaccharides) that modulates the intestinal microbiota, thereby increasing nutrient absorption and promoting intestinal health.
Other products
Biorigin’s portfolio also includes the products Nutricell (inactive dry yeast derived from alcohol fermentation), Brewcell (brewer’s inactive dry yeast), HiCell (autolyzed yeast), Primecell (hydrolyzed yeast), Selemax (organic selenium), Protemyc (mycotoxin adsorbent), and ProWean (triple-action package for weaning animals).
Visit the Biorigin website HERE.
The project is funded by the research aid agency of the state of São Paulo (Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP), and the Netherlands Organisation for Scientific Research (NOW), and aims at identifying the receptors responsible for recognizing beta-glucans in carp and pacu macrophages.
According to Prof Dr Geert Wiegertjes, from Wageningen University, “similarly to cold-water fish such as salmon, carp macrophages are strongly activated by the product MacroGard, as demonstrated by the increase in oxidative burst and gene expression.
“In this project, we intend to demonstrate that this same activation occurs in pacu macrophages. As this activation depends on specific receptors, in a second phase, we will research the receptors responsible for this mechanism in carps and pacus, which may potentially prove that beta-glucans have a similar mode of action both in fish and mammals.”
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| Pacu |
According to Prof Dr Fabiana Pilarski, from UNESP, “the partnership with Biorigin has now been going for 7 years and has been very fruitful, with the development of 4 research projects to date. Our studies have shown that the product MacroGard acts on the immune system of tropical fish, particularly when reared in intensive systems and during challenge situations, reducing the harmful effects of stress and promoting better performance.
“We also carried out studies with the product ActiveMOS, which was shown to efficiently reduce pathogenic bacteria counts and the number of beneficial bacteria, such as lactobacilli and bifidobacteria, in addition of promoting the development of the structures responsible for nutrient absorption in the gut of fish.”
It is estimated that the aquaculture industry will grow 25 percent in the next few years, and Biorigin has placed 60 percent of its investments in research on animal nutrition, establishing partnerships with universities and research institutes of several countries.
MacroGard
Produced by Biorigin from the cell wall of the yeast Saccharomyces cerevisiae, MacroGard is one of the most studied purified beta-glucans in the world, with proven results such as boosting the immune response and resistance to diseases caused by parasites and viruses, improving vaccine response, and reducing the severity of diseases and mortality.
ActiveMOS
This Biorigin product is rich in MOS (mannan-oligosaccharides) that modulates the intestinal microbiota, thereby increasing nutrient absorption and promoting intestinal health.
Other products
Biorigin’s portfolio also includes the products Nutricell (inactive dry yeast derived from alcohol fermentation), Brewcell (brewer’s inactive dry yeast), HiCell (autolyzed yeast), Primecell (hydrolyzed yeast), Selemax (organic selenium), Protemyc (mycotoxin adsorbent), and ProWean (triple-action package for weaning animals).
Visit the Biorigin website HERE.
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